Therefore the virus requires its own polymerase to perform the primary transcription of mRNA from the anti-genomic RNP and initiate the viral life cycle within the infected cell. After a threshold of transcription has been achieved and a certain amount of viral proteins has been produced the polymerase switches to replication mode in which it ignores stop and start signals used to.
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Use of vectors based on measles virus MV a negative single-stranded RNA virus is relatively new to the HIV vaccine arena yet recombinants encoding numerous other viral genes have been constructed including those of hepatitis B mumps West Nile virus and severe acute respiratory syndrome coronavirus SARS.
. The MV vector presents several features that would.
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